| Symbol
| LINGO1
| contributors: mct/pgu - updated : 26-09-2017
|
| HGNC name
| leucine rich repeat and Ig domain containing 1
|
| HGNC id
| 21205
|
| corresponding disease(s)
|
MRT64
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in the substantia nigra of Parkinson's disease (PD) patients | | constitutional
|
|
| --over
|
|
in the cerebellar cortex of Essential tremor (ET) in patients compared with controls, particularly in individuals with longer disease duration  | |
| Susceptibility
|
to essential tremor (ET) |
| Variant & Polymorphism
SNP
| Significant association was found with allele G of marker rs9652490 in essential tremor |
|
a marker rs9652490, showing significant genome-wide association with essential tremor (ET) |
|
relationship between LINGO1 rs11856808 polymorphism and the risk for ET and for familial ET, while rs9652490 polymorphism was only related with the risk for familial ET |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| neurology | neurodegenerative | | |
| targeted inhibition of LINGO1 presents a novel therapeutic approach for the treatment of neurological diseases | | neurology | dystonia | | |
| antagonism of LINGO1 may be a worthwhile approach to the treatment of some diseases of the central nervous system (essential tremor is on the top of the list of diseases to be assessed) | | neuromuscular | neuropathy | | |
| Antagonism of LINGO-1 or its pathway is therefore a promising approach for the treatment of demyelinating diseases of the CNS | | neurology | acquired | | |
| treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury | | neurology | neurodegenerative | | |
| target for the treatment of demyelination diseases | | neurology | neurodegenerative | | |
| is a potential drug target for essential tremor |
| | | |
|
| Increased axon integrity observed in LINGO1 mouse knockout models highlights the potential role of LINGO1 in the pathophysiology of essential tremor and opens up a new field in the research into essential tremor |