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FLASH GENE
Symbol PLPPR5 contributors: mct/npt - updated : 07-09-2020
Location 1p21.3      Physical location : -
Genatlas name lipid phosphate phosphatase-related protein type 5
Synonym name
  • phosphatidic acid phosphatase type 2
  • plasticity-related gene 5 protein
  • Synonym symbol(s) PAP2, PRG5, PAP2D, LPPR5,
    DNA
    TYPE functioning gene
    STRUCTURE 114.65 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4023 - 321 mainly expressed in brain, lung, kidney, testis and colon 2010 20032306
    6 - 4008 - 316 restricted to placenta, skeletal muscle, and kidney 2010 20032306
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral lobefrontal lobe 
     nerve   highly
    Reproductivemale systemprostate   
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a well-conserved PAP2 motif
  • HOMOLOGY
    interspecies homolog to to PRG3
    Homologene
    FAMILY
  • plasticity-related gene family, PLPPR family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text in neurons, distributed in the plasma membrane and induces filopodia as well as axon elongation and growthb (Broggini 2010)
    basic FUNCTION
  • induces filopodia growth independently of CDC42 (Broggini 2010)
  • impedes brain injury-associated growth inhibitory signals upstream of the RhoA-Rho kinase pathway (Broggini 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
  • cell & other
    REGULATION
    Other regulated during brain and spinal cord development and is exclusively allocated within the nervous system (Broggini 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS