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FLASH GENE
Symbol SLC25A45 contributors: mct - updated : 06-11-2020
HGNC name solute carrier family 25, member 45
HGNC id 27442
Location 11q13.1      Physical location : 65.142.662 - 65.150.142
Synonym symbol(s) FLJ42028
DNA
TYPE functioning gene
STRUCTURE 8.51 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2261 - 288 - 2006 16949250
6 - 2206 - 246 - 2006 16949250
10 - 3091 - 246 - 2006 16949250
5 - 2020 - 184 - 2006 16949250
5 - 2030 - 264 - 2006 16949250
7 - 2320 - 246 - 2006 16949250
5 - 1916 - 226 - 2006 16949250
6 - 2102 - 288 - 2006 16949250
5 - 1975 - 184 - 2006 16949250
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Lymphoid/Immunespleen   highly
Nervousbrainforebraincerebral cortex highly
 nervecranial nerve  highly
Olfactory (smell)olfactory bulb   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • SLC25A45 is a transport protein in the mitochondrial membrane, containing active thyroid-responsive elements
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to mucinous histological subtype of epithelial ovarian cancer
    Variant & Polymorphism
  • SNP of SLC25A45 was associated with the mucinous histological subtype of epithelial ovarian cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS