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FLASH GENE

Symbol

SLC25A44

contributors: mct - updated : 10-05-2014

HGNC name	solute carrier family 25, member 44
HGNC id	29036

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q22      Physical location : 156.163.729 - 156.182.586
Synonym symbol(s)	FLJ90431, KIAA0446, RP11-54H19.3

DNA

TYPE	functioning gene
STRUCTURE	18.86 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001286184 4 - 3684 NP_001273113 - 322 - 2006 16949250 NM_014655 4 - 3660 NP_055470 - 314 - 2006 16949250

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Endocrine parathyroid       highly Nervous brain basal nuclei corpus callosum   highly Homo sapiens   brain hindbrain cerebellum   highly Homo sapiens   brain diencephalon epithalamus   highly Homo sapiens Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four EF-hand domains
	three solcar repeats

HOMOLOGY

Homologene

FAMILY

mitochondrial carrier family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	calcium-dependent mitochondrial aspartate and glutamate carrier
	may have a function in the urea cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Intracerebral Hemorrhage, non lobar

Variant & Polymorphism SNP	variants within 1q22 are located in an LD block of 48 kb that contains PMF1 and SLC25A44 associated with the risk of Intracerebral Hemorrhage, non lobar

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS