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FLASH GENE
Symbol SLC25A43 contributors: mct - updated : 06-11-2020
HGNC name solute carrier family 25, member 43
HGNC id 30557
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three solcar repeats
HOMOLOGY
interspecies ortholog to murine Slc25a43 (86 pc)
Homologene
FAMILY mitochondrial carrier family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • required for the accumulation of coenzyme a in the mitochondrial matrix
  • epigenetic changes in SLC25A43 gene could likely be of importance in breast carcinogenesis
  • role for SLC25A43 as a regulator of cell cycle progression and proliferation through a putative mitochondrial checkpoint
  • SLC25A43 expression is altered at the gene and protein levels in basal cell carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HARTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in basal cell carcinoma compared with healthy skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS