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FLASH GENE
Symbol SLC25A43 contributors: mct - updated : 06-11-2020
HGNC name solute carrier family 25, member 43
HGNC id 30557
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 stomach   highly
Nervousbrainhindbraincerebellum highly
 brainforebraincerebral cortex highly
Olfactory (smell)olfactory bulb   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three solcar repeats
HOMOLOGY
interspecies ortholog to murine Slc25a43 (86 pc)
Homologene
FAMILY mitochondrial carrier family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • required for the accumulation of coenzyme a in the mitochondrial matrix
  • epigenetic changes in SLC25A43 gene could likely be of importance in breast carcinogenesis
  • role for SLC25A43 as a regulator of cell cycle progression and proliferation through a putative mitochondrial checkpoint
  • SLC25A43 expression is altered at the gene and protein levels in basal cell carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HARTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in basal cell carcinoma compared with healthy skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS