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FLASH GENE
Symbol EEF1AKMT3 contributors: mct - updated : 11-01-2021
HGNC name EEF1A lysine methyltransferase 3
HGNC id 24936
Location 12q14.1      Physical location : -
Synonym name
  • hepatocellular carcinoma-associated antigen HCA557a
  • hypothetical protein LOC25895
  • family with sequence similarity 119, member B
  • Synonym symbol(s) DKFZP586D0919, HCA557A, FAM119B, METTL21B
    EC.number 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.94 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2717 24 226 - 217 28663172
    4 - 2856 - 149 - 217 28663172
    an alternate coding exon that causes a frameshift and has a distinct C-terminus
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to murine LOC546486
    Homologene
    FAMILY
  • FAM119 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • METTL21B accumulated in centrosomes, in addition to the expected cytosolic localization
  • basic FUNCTION
  • with METTL21A, EEF1AKMT3, METTL21C methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease
  • is the enzyme responsible for methylation of eEF1A on Lys-165 and this modification is dynamic, inducible and likely of regulatory importance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS