Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZBTB38 contributors: mct - updated : 28-06-2022
HGNC name zinc finger and BTB domain containing 38
HGNC id 26636
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thirteen C2H2-type zinc fingers
  • Kaiso-like zinc fingers
  • two caspase-3 cleavage sites
  • a SP domain with two putative bipartite nuclear localization signals, at AA 845
    • 865 and 922
    940, and the second cleavage site DSTD situated between them
  • C-terminal Zinc finger of ZBTB38 can directly occupy promoters harboring the newly identified sequence motif in cell in a methyl-dependent manner and, depending on the gene context, contribute to modulating transcriptional response
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • zinc finger (ZF) family of methyl-CpG binding proteins
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a cardiac regulator and an effector of alpha1-adrenergic signaling
  • may be involved in the maintenance of panneuronal features and/or in the survival of mature neurons
  • able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests non-overlapping functions
  • having a physiological function, participating in the negative regulation of apoptosis
  • promoted likely epithelial&
    • 8209;mesenchymal transition and the expression levels of genes downstream of the Wnt/CTNNB1 signaling pathway
  • may promote migration and invasive growth of bladder cancer cells via modulation of the Wnt/CTNNB1 signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding, bind methylated DNA
    RNA
    small molecule
    protein
  • binds to PE response elements (PERE) present in the promoter of genes such as NPPA and acts as a direct transcriptional activator of NPPA
  • also acts as a cofactor with GATA4, a key cardiac regulator
  • substrate for caspase-3
  • ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and they may use a mode of binding common to other zinc-finger proteins
  • E3 ubiquitin ligase RBBP6 ubiquitinates and destabilizes the transcriptional repressor ZBTB38, and this pathway ensures genome-wide DNA replication and chromosomal stability
  • deubiquitinase, USP9X interacts with ZBTB38, deubiquitinates it, and stabilizes it
  • ZBTB38 could repress cell migration and proliferation in prostate cancer via promoting DKK1 expression
  • ZBTB38 is essential for early embryonic development via the suppression of NANOG and SOX2 expression
    • cell & other
    REGULATION
    activated by activation of alpha1-adrenergic receptors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer tissues, which also strongly predicts a poorer prognosis of prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ZBTB38 is a potential prognosis marker for prostate cancer
    • Therapy target
    ANIMAL & CELL MODELS