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FLASH GENE

Symbol

ZBTB38

contributors: mct - updated : 28-06-2022

HGNC name	zinc finger and BTB domain containing 38
HGNC id	26636

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine adrenal gland       highly   parathyroid       highly Lymphoid/Immune lymph node       highly Nervous brain         Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text

heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	thirteen C2H2-type zinc fingers
	Kaiso-like zinc fingers
	two caspase-3 cleavage sites
	a SP domain with two putative bipartite nuclear localization signals, at AA 845
	865 and 922
	940, and the second cleavage site DSTD situated between them
	C-terminal Zinc finger of ZBTB38 can directly occupy promoters harboring the newly identified sequence motif in cell in a methyl-dependent manner and, depending on the gene context, contribute to modulating transcriptional response

HOMOLOGY

Homologene

FAMILY	krueppel C2H2-type zinc-finger protein family
	zinc finger (ZF) family of methyl-CpG binding proteins

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as a cardiac regulator and an effector of alpha1-adrenergic signaling
	may be involved in the maintenance of panneuronal features and/or in the survival of mature neurons
	able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests non-overlapping functions
	having a physiological function, participating in the negative regulation of apoptosis
	promoted likely epithelial&
	8209;mesenchymal transition and the expression levels of genes downstream of the Wnt/CTNNB1 signaling pathway
	may promote migration and invasive growth of bladder cancer cells via modulation of the Wnt/CTNNB1 signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	DNA binding, bind methylated DNA

RNA

small molecule

protein	binds to PE response elements (PERE) present in the promoter of genes such as NPPA and acts as a direct transcriptional activator of NPPA
	also acts as a cofactor with GATA4, a key cardiac regulator
	substrate for caspase-3
	ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and they may use a mode of binding common to other zinc-finger proteins
	E3 ubiquitin ligase RBBP6 ubiquitinates and destabilizes the transcriptional repressor ZBTB38, and this pathway ensures genome-wide DNA replication and chromosomal stability
	deubiquitinase, USP9X interacts with ZBTB38, deubiquitinates it, and stabilizes it
	ZBTB38 could repress cell migration and proliferation in prostate cancer via promoting DKK1 expression
	ZBTB38 is essential for early embryonic development via the suppression of NANOG and SOX2 expression

cell & other

REGULATION

activated by

activation of alpha1-adrenergic receptors

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in prostate cancer tissues, which also strongly predicts a poorer prognosis of prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ZBTB38 is a potential prognosis marker for prostate cancer
Therapy target

ANIMAL & CELL MODELS