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FLASH GENE

Symbol

HPCAL1

contributors: npt/ - updated : 21-04-2008

HGNC name	hippocalcin-like 1
HGNC id	5145

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	124.70 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1769 22.2 193 - - utilizing a different exon and also lacking one exon in the 5' UTR encoded protein is the same variant 2 - splicing 1920 22.2 193 - - utilizing an alternative exon of 243 bases instead of exon 1 and containing an additional exon of 173 bases in the 5' UTR encoding the same protein

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine hippocalcin like-1
	homolog to rattus hippocalcin like-1
	homolog to Drosophila Nca
	homolog to C.elegans ncs-3

intraspecies

homolog to hippocalcin

Homologene

FAMILY	neuron-specific calcium-binding proteins family
	recoverin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in the calcium-dependent regulation of rhodopsin phosphorylation
	may be of relevance for neuronal signaling in the central nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to actin, tubulin, clathrin
	NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS