Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HRH1 contributors: mct - updated : 23-12-2011
HGNC name histamine receptor H1
HGNC id 5182
Location 3p25      Physical location : 11.178.778 - 11.304.938
Synonym name histamine receptor, subclass H1
Synonym symbol(s) H1R, hisH1
DNA
TYPE functioning gene
STRUCTURE 126.16 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
HCP10 3p25.3 cytochrome c, somatic pseudogene LOC389094 3 LOC389094 CICE 3p25.3 cell death-inducing CIDE-like effector pseudogene FANCD2 3p25.3 Fanconi anemia, complementation group D2 HCP11 3p25.3 cytochrome c, somatic pseudogene MGC40179 3p25.3 hypothetical protein MGC40179 MDS027 3p25.3 uncharacterized hematopoietic stem/progenitor cells protein MDS027 VHL 3p26-p25 von Hippel-Lindau syndrome IRAK2 3p25.3 interleukin-1 receptor-associated kinase 2 KIAA0218 3p25.3 interleukin-1 receptor-associated kinase 2 NAG73 3p26-p25 NPC-related protein NAG73 GHRL 3p26-p25 NPC-related protein NAG73 SEC13L1 3p25-p24 SEC13-like 1 (S. cerevisiae) ATP2B2 3p25-p24 ATPase, Ca++ transporting, plasma membrane 2 LOC389095 3 LOC389095 SLC6A11 3p25.2 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 SLC6A1 3p25-p24 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 LOC391509 3 similar to Drosophila melanogaster CG8797 gene product-related LOC391510 3 similar to FLJ31709 protein HRH1 3p25 histamine receptor H1 APG7L 3p25.3-3p24.1 APG7 autophagy 7-like (S. cerevisiae) KIAA0121 3p25.2 KIAA0121 gene product LOC132001 3p25.2 hypothetical protein BC015088 DKFZp434E0519 3p25.2 hypothetical protein DKFZp434E0519 HCP12 3p25.2 cytochrome c, somatic pseudogene SYN2 3p25 synapsin II TIMP4 3p25 tissue inhibitor of metalloproteinase 4 LOC391511 3 similar to Glutathione S-transferase Mu 1 (GSTM1-1) (HB subunit 4) (GTH4) (GSTM1a-1a) (GSTM1b-1b) (GST class-mu 1) PPARG 3p25 peroxisome proliferative activated receptor, gamma
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4427 - 487 - 2011 21697825
  • isoform H/I/K
  • 2 - 4348 - 487 - 2011 21697825
  • isoform F/K
  • 2 - 4298 - 487 - 2011 21697825
  • isoform B/K
  • 2 - 4578 - 487 - 2011 21697825
  • isoform A/K
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly Homo sapiens
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • activating adenylate cyclase
  • stimulating contraction on smooth muscle in the gut and bronchs and decreasing blood pressure
  • induces cytosolic calcium increase and aquaporin translocation in salivary gland cells
  • endothelial HRH1 expression reduces blood-brain barrier permeability, suggesting that endothelial HRH1 signaling may be important in the maintenance of cerebrovascular integrity
  • histamine signaling through the HRH1 ondendritic cells is an important early event conditioning the quality of the skin effector immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    protein
    cell & other
    REGULATION
    activated by CHRM3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with allergic rhinitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS