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FLASH GENE
Symbol PDILT contributors: mct/npt - updated : 10-12-2013
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two thioredoxin domains
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • protein disulfide isomerase family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having specialized chaperone function in testicular cells
  • catalyzing the rearrangement of -s-s- bonds in proteins
  • first eukaryotic SXXC protein to be characterized in the ER
  • ER resident glycoprotein that liaises with partner proteins in disulfide-dependent complexes within the testis
  • induced during puberty and represents the first example of a PDI family member under developmental control
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a tissue-specific chaperone complex with the calnexin homologue calmegin (CLGN)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the oxidoreductase ERO1L, demonstrating that the N-terminal cysteine of the CXXC sequence is not required for binding of PDI family proteins to ER oxidoreductases
  • cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pdilt-/- mice were male infertile because Adam3 could not be folded properly and transported to the sperm surface without the Pdilt/Calr3 complex