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FLASH GENE
Symbol TXNDC11 contributors: mct - updated : 30-08-2022
HGNC name thioredoxin domain containing 11
HGNC id 28030
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two thioredoxin domains
  • five thioredoxin (Trx)-like domains
    • HOMOLOGY
    Homologene
    FAMILY thioredoxin-related protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may act as a redox regulator involved in DUOX proteins folding
  • could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the cytoplasmic part of DUOX1 and DUOX2
  • interacts with TPO and CYBA
  • EDEM1, EDEM2 associate with oxidoreductases, protein disulfide isomerase, and especially TXNDC11, enhancing mannosidase activity on glycoproteins but not on free N-glycans
  • EDEM2 was stably disulfide-bonded to TXNDC11, an endoplasmic reticulum protein containing five thioredoxin (Trx)-like domains
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioma, and high TXNDC11 expression was associated with poor overall survival (OS) and worse clinical prognostic variables
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of TXNDC11 may predict unfavorable prognosis of glioma patients
    • Therapy target
    ANIMAL & CELL MODELS