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FLASH GENE

Symbol

TXNDC11

contributors: mct - updated : 30-08-2022

HGNC name	thioredoxin domain containing 11
HGNC id	28030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.13      Physical location : 11.772.942 - 11.836.648
Synonym name	EF-hand binding protein 1
Synonym symbol(s)	EFP1

DNA

TYPE	functioning gene
STRUCTURE	63.00 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001324025 12 - 2873 NP_001310954 - 506 - 2020 32065582 NM_001324022 11 - 2986 NP_001310951 - 744 - 2020 32065582 NM_001324024 11 - 3003 NP_001310953 - 506 - 2020 32065582 NM_015914 12 - 3116 NP_056998 - 958 - 2020 32065582 NM_001303447 12 - 3197 NP_001290376 - 985 - 2020 32065582

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   mouth tongue     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two thioredoxin domains
	five thioredoxin (Trx)-like domains

HOMOLOGY

Homologene

FAMILY

thioredoxin-related protein family

CATEGORY

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	may act as a redox regulator involved in DUOX proteins folding
	could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with the cytoplasmic part of DUOX1 and DUOX2
	interacts with TPO and CYBA
	EDEM1, EDEM2 associate with oxidoreductases, protein disulfide isomerase, and especially TXNDC11, enhancing mannosidase activity on glycoproteins but not on free N-glycans
	EDEM2 was stably disulfide-bonded to TXNDC11, an endoplasmic reticulum protein containing five thioredoxin (Trx)-like domains

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioma, and high TXNDC11 expression was associated with poor overall survival (OS) and worse clinical prognostic variables

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	high expression of TXNDC11 may predict unfavorable prognosis of glioma patients
Therapy target

ANIMAL & CELL MODELS