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FLASH GENE
Symbol WIPI2 contributors: mct - updated : 10-10-2022
HGNC name WD repeat domain, phosphoinositide interacting 2
HGNC id 32225
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 7-bladed propeller structure
  • a conserved motif for interaction with phospholipids
  • three WD repeats
    • HOMOLOGY
    Homologene
    FAMILY
  • WIPI subfamily of WD40 repeat proteins
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions
  • WIPI1 and WIPI2 as novel protein components of autophagosomes, and of membrane sites from which autophagosomes might originate (ER, PM, Golgi area)
  • WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome
  • WIPI2 protein level regulated by MTORC1 and HUWE1 is a pivotal determinant of cellular autophagy intensity
  • robust mechanism for autophagosome formation in which WIPI2 may be one component of the preferential, but not sole, machinery with the potential to orchestrate autophagosome formation (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WIPI2 is a phosphorylation substrate of CRTC1 and a ubiquitination target of HUWE1
  • interface between WIPI2 and ATG16L1 mediates autophagosome formation under starvation conditions
  • WIPI2 binds to and promotes AAA-ATPase VCP/p97 to damaged mitochondria
    • cell & other
    REGULATION
    Other dynamic and local phosphorylation of WIPI2 is a critical regulatory step in autophagosome biogenesis in neurons and this step is specifically affected by aging
    ASSOCIATED DISORDERS
    corresponding disease(s) IDSSA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS