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FLASH GENE
Symbol THG1L contributors: mct - updated : 18-10-2022
HGNC name tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
HGNC id 26053
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • tRNA(His) guanylyltransferase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • is specifically localized to mitochondria
    • basic FUNCTION
  • expressed in a cell cycle-dependent manner and may be involved in cell cycle progression and cell proliferation
  • mitochondria modulate TGFB1 signal transduction and THG1L is a key player in this modulation
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • THG1L increases mitochondrial biogenesis by promoting PPARGC1A-dependent processes, potentially contributing to the pathogenesis of renal fibrosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS