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FLASH GENE
Symbol THG1L contributors: mct - updated : 18-10-2022
HGNC name tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
HGNC id 26053
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
 liver   moderately
 stomach   highly
Endocrineneuroendocrinepituitary  highly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • tRNA(His) guanylyltransferase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • is specifically localized to mitochondria
    • basic FUNCTION
  • expressed in a cell cycle-dependent manner and may be involved in cell cycle progression and cell proliferation
  • mitochondria modulate TGFB1 signal transduction and THG1L is a key player in this modulation
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • THG1L increases mitochondrial biogenesis by promoting PPARGC1A-dependent processes, potentially contributing to the pathogenesis of renal fibrosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS