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FLASH GENE

Symbol

THG1L

contributors: mct - updated : 18-10-2022

HGNC name	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
HGNC id	26053

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	10.03 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017872 6 - 2885 NP_060342 - 298 - 2021 33682303 NM_001317825 6 - 2881 NP_001304754 - 173 - 2021 33682303 NM_001317824 6 - 2790 NP_001304753 - 166 - 2021 33682303 NM_001317826 7 - 2898 NP_001304755 - 236 - 2021 33682303

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine small intestine     highly   liver       moderately   stomach       highly Endocrine neuroendocrine pituitary     highly Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, interphase

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

tRNA(His) guanylyltransferase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	is specifically localized to mitochondria

basic FUNCTION	expressed in a cell cycle-dependent manner and may be involved in cell cycle progression and cell proliferation
	mitochondria modulate TGFB1 signal transduction and THG1L is a key player in this modulation

CELLULAR PROCESS	cell cycle, progression

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

THG1L increases mitochondrial biogenesis by promoting PPARGC1A-dependent processes, potentially contributing to the pathogenesis of renal fibrosis

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS