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FLASH GENE
Symbol THG1L contributors: mct - updated : 18-10-2022
HGNC name tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
HGNC id 26053
Location 5q33.3      Physical location : 157.158.322 - 157.166.771
Synonym name
  • interphase cyctoplasmic foci protein 45
  • probable tRNA(His) guanylyltransferase
  • hisguanylyltransferase
  • induced by high glucose-1
    • Synonym symbol(s) FLJ20546, ICF45, FLJ11601, IHG-1, IHG1, SCAR28, THG1, hTHG1
    EC.number 2.7.7.79
    DNA
    TYPE functioning gene
    STRUCTURE 10.03 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2885 - 298 - 2021 33682303
    6 - 2881 - 173 - 2021 33682303
    6 - 2790 - 166 - 2021 33682303
    7 - 2898 - 236 - 2021 33682303
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     liver   moderately
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • tRNA(His) guanylyltransferase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • is specifically localized to mitochondria
    • basic FUNCTION
  • expressed in a cell cycle-dependent manner and may be involved in cell cycle progression and cell proliferation
  • mitochondria modulate TGFB1 signal transduction and THG1L is a key player in this modulation
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • THG1L increases mitochondrial biogenesis by promoting PPARGC1A-dependent processes, potentially contributing to the pathogenesis of renal fibrosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS