basic FUNCTION
| involved in the processing of Wnt (wingless and int homologue) proteins (regulator of Wnt signaling) |
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multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family |
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might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma |
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importance of PORCN for WNT secretion and gastrulatio, suggesting that disruption of early development underlies the male lethality of human PORCN mutants |
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appears to moonlight in a novel signaling pathway that is rate-limiting for cancer cell growth and tumorigenesis independent of its enzymatic function in Wnt biosynthesis and secretion |
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membrane-bound O-acyltransferase that is required for post-translational modification of all Wnts to enable their transport, secretion, and activity |
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is a key non-redundant node for the regulation of global Wnt signaling because PORCN null cells are completely incapable of autocrine Wnt signaling |
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importance of palmitoylation for WNT1 activity and PORCN is an O-acyl transferase for WNT1 |
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roles for PORCN in controlling synaptic transmission by regulating the level and composition of hippocampal AMPAR complexes |