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FLASH GENE
Symbol LIN9 contributors: mct - updated : 24-10-2014
HGNC name lin-9 homolog (C. elegans)
HGNC id 30830
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunelymph node   moderately
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Lin9 (96.4 pc)
Homologene
FAMILY
CATEGORY regulatory , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
text
  • perinucleolar structures
    • basic FUNCTION
  • inhibiting DNA synthesis
  • inhibiting oncogenic transformation
  • playing a role in the expression of genes required for the G1/S transition
  • can inhibit cell proliferation independent of the pocket proteins
  • LIN9 and MYBL2 were both required for transcription of G(2)/M genes such as CCCNB1 and Survivin
  • role of LIN9 in development and mitotic gene regulation, suggesting that it may function as a haploinsufficient tumor suppressor
  • depletion of LIN9 results in downregulation of mitotic genes and in upregulation of differentiation-specific genes
  • is essential for proliferation and genome stability of ESCs by activating genes with important functions in mitosis and cytokinesis
    • CELLULAR PROCESS cell cycle
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • LIN9 and the pocket proteins RBL1 and RBL2 are members of the DREAM complex that in G0 represses cell cycle genes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RB1
  • KIA1456 and tRNA modifications are linked to inhibition of tumour growth via LIN9 and HIF1A-dependent mechanisms
    • cell & other
    REGULATION
    Phosphorylated by CCNE1/CDK3, that phosphorylates LIN9 on Thr-96
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS