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FLASH GENE

Symbol

LIN9

contributors: mct - updated : 24-10-2014

HGNC name	lin-9 homolog (C. elegans)
HGNC id	30830

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	78.94 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001270410 15 - 3073 NP_001257339 - 490 - 2007 17159899 NM_001270409 14 - 3240 NP_001257338 - 523 - 2007 17159899 NM_173083 15 - 3345 NP_775106 - 558 - 2007 17159899

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune lymph node       moderately   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to murine Lin9 (96.4 pc)

Homologene

FAMILY

CATEGORY

regulatory , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	perinucleolar structures

basic FUNCTION	inhibiting DNA synthesis
	inhibiting oncogenic transformation
	playing a role in the expression of genes required for the G1/S transition
	can inhibit cell proliferation independent of the pocket proteins
	LIN9 and MYBL2 were both required for transcription of G(2)/M genes such as CCCNB1 and Survivin
	role of LIN9 in development and mitotic gene regulation, suggesting that it may function as a haploinsufficient tumor suppressor
	depletion of LIN9 results in downregulation of mitotic genes and in upregulation of differentiation-specific genes
	is essential for proliferation and genome stability of ESCs by activating genes with important functions in mitosis and cytokinesis

CELLULAR PROCESS	cell cycle
	nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

LIN9 and the pocket proteins RBL1 and RBL2 are members of the DREAM complex that in G0 represses cell cycle genes

INTERACTION

DNA

RNA

small molecule

protein	interacting with RB1
	KIA1456 and tRNA modifications are linked to inhibition of tumour growth via LIN9 and HIF1A-dependent mechanisms

cell & other

REGULATION

Phosphorylated by

CCNE1/CDK3, that phosphorylates LIN9 on Thr-96

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS