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FLASH GENE
Symbol LIN9 contributors: mct - updated : 24-10-2014
HGNC name lin-9 homolog (C. elegans)
HGNC id 30830
Location 1q42.12      Physical location : 226.418.860 - 226.497.198
Synonym name
  • beta-subunit associated regulator of apoptosis
  • rb related pathway actor
  • TUDOR gene similar protein
  • beta subunit-associated regulator of apoptosis
  • type I interferon receptor beta chain-associated protein
    • Synonym symbol(s) TGS, BARA, BARPsv, TGS1, Lin-9, TGS1, TGS2
    DNA
    TYPE functioning gene
    STRUCTURE 78.94 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3073 - 490 - 2007 17159899
    14 - 3240 - 523 - 2007 17159899
    15 - 3345 - 558 - 2007 17159899
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunelymph node   moderately
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Lin9 (96.4 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • perinucleolar structures
    • basic FUNCTION
  • inhibiting DNA synthesis
  • inhibiting oncogenic transformation
  • playing a role in the expression of genes required for the G1/S transition
  • can inhibit cell proliferation independent of the pocket proteins
  • LIN9 and MYBL2 were both required for transcription of G(2)/M genes such as CCCNB1 and Survivin
  • role of LIN9 in development and mitotic gene regulation, suggesting that it may function as a haploinsufficient tumor suppressor
  • depletion of LIN9 results in downregulation of mitotic genes and in upregulation of differentiation-specific genes
  • is essential for proliferation and genome stability of ESCs by activating genes with important functions in mitosis and cytokinesis
    • CELLULAR PROCESS cell cycle
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • LIN9 and the pocket proteins RBL1 and RBL2 are members of the DREAM complex that in G0 represses cell cycle genes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RB1
  • KIA1456 and tRNA modifications are linked to inhibition of tumour growth via LIN9 and HIF1A-dependent mechanisms
    • cell & other
    REGULATION
    Phosphorylated by CCNE1/CDK3, that phosphorylates LIN9 on Thr-96
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS