Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LIME1

contributors: mct - updated : 03-04-2023

HGNC name	Lck interacting transmembrane adaptor 1
HGNC id	26016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	transmembrane adaptor protein mediating TCR-dependent T cell activation
	LIME is a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of VAV1
	raft-associated transmembrane protein expressed predominantly in T and B lymphocytes
	is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Attention-deficit/hyperactivity disorder (ADHD) to multiple sclerosis

Variant & Polymorphism other	DNA methylation of two CpG sites in LIME1 is associated with attention deficits in children

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS