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FLASH GENE
Symbol LIME1 contributors: mct - updated : 03-04-2023
HGNC name Lck interacting transmembrane adaptor 1
HGNC id 26016
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY adaptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • transmembrane adaptor protein mediating TCR-dependent T cell activation
  • LIME is a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of VAV1
  • raft-associated transmembrane protein expressed predominantly in T and B lymphocytes
  • is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Attention-deficit/hyperactivity disorder (ADHD)
  • to multiple sclerosis
    • Variant & Polymorphism other
  • DNA methylation of two CpG sites in LIME1 is associated with attention deficits in children
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS