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FLASH GENE

Symbol

ADCY5

contributors: mct - updated : 03-01-2017

HGNC name	adenylate cyclase 5
HGNC id	236

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	164.00 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_183357 21 - 3842 NP_899200 - 1261 - Haber (1994)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one N terminal guanylate cyclase domain
	a DUF1053 domain
	one C terminal guanylate cyclase domain

HOMOLOGY

Homologene

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	adenylyl cyclase, type V, catalyzing the formation of the secondary messenger cyclic adenosine monophosphate (cAMP)
	not implicated in early insulin secretion in response to an oral glucose load, but contributes to risk for T2D (Saxena 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	dynamic regulation of cAMP synthesis through anchored PRKACA -ADCY5, ADCY6 and AKAP5 complex
	interacts with RIC8A through directly interacting at its N-terminus
	interacting with RGS2
	interacting with G protein betagamma subunit
	PKD2 interacts with ADCY5 through its C terminus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FDFM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)

Susceptibility

to type 2 diabetes in sujets with reduced birthweight

Variant & Polymorphism SNP	rs11708067 increasing the risk of type 2 diabetes in sujets with reduced birthweight (Andersson 2010)
	Allele A of rs11708067, associated with a higher risk of type 2 diabetes (Freathy 2010)
	(rs11708067 displayed evidence for association with type 2 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS