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FLASH GENE
Symbol LETM2 contributors: mct - updated : 23-05-2023
HGNC name leucine zipper-EF-hand containing transmembrane protein 2
HGNC id 14648
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative leucine zipper coiled coil domain (i.e., between residues 208–235), but lacks the putative EF-hand motif and is significantly smaller than LETM1
    • HOMOLOGY
    intraspecies paralog to LETM1
    Homologene
    FAMILY LETM1 protein family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • LETM2 may facilitate tumor progression by activating the PI3K-Akt signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LETM2 could activate the downstream PI3K-Akt pathway to participate in PDAC development
  • LETM2 may activate the downstream PI3K-Akt signaling pathway through enhancing the level of PI3K phosphorylation as well as Akt phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in squamous lung carcinomas
    tumoral     --over  
    was correlated with poor outcomes of pancreatic ductal adenocarcinoma (PDAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS