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FLASH GENE
Symbol LETM2 contributors: mct - updated : 23-05-2023
HGNC name leucine zipper-EF-hand containing transmembrane protein 2
HGNC id 14648
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative leucine zipper coiled coil domain (i.e., between residues 208–235), but lacks the putative EF-hand motif and is significantly smaller than LETM1
    • HOMOLOGY
    intraspecies paralog to LETM1
    Homologene
    FAMILY LETM1 protein family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • LETM2 may facilitate tumor progression by activating the PI3K-Akt signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LETM2 could activate the downstream PI3K-Akt pathway to participate in PDAC development
  • LETM2 may activate the downstream PI3K-Akt signaling pathway through enhancing the level of PI3K phosphorylation as well as Akt phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in squamous lung carcinomas
    tumoral     --over  
    was correlated with poor outcomes of pancreatic ductal adenocarcinoma (PDAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS