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FLASH GENE

Symbol

LETM2

contributors: mct - updated : 23-05-2023

HGNC name	leucine zipper-EF-hand containing transmembrane protein 2
HGNC id	14648

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	cluster
SPECIAL FEATURE
text	region comprises a cluster of genes containing LETM2, FGFR1, and WHSC1L1
STRUCTURE	27.09 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001363204 11 - 2979 NP_001350133 - 310 - 2008 18628306 NM_001286819 11 - 2856 NP_001273748 - 491 - 2008 18628306 NM_001286787 11 - 2771 NP_001273716 - 288 - 2008 18628306 NM_001330515 10 - 2712 NP_001317444 - 443 - 2008 18628306 NM_001199659 11 - 2785 NP_001186588 - 444 - 2008 18628306 NM_001363205 11 - 2700 NP_001350134 - 288 - 2008 18628306 NM_144652 10 - 2641 NP_653253 - 396 - 2008 18628306 NM_001286821 3 - 2086 NP_001273750 - 173 - 2008 18628306 NM_001199660 11 - 2648 NP_001186589 - 288 - 2008 18628306

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a putative leucine zipper coiled coil domain (i.e., between residues 208–235), but lacks the putative EF-hand motif and is significantly smaller than LETM1

HOMOLOGY

intraspecies

paralog to LETM1

Homologene

FAMILY

LETM1 protein family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION

LETM2 may facilitate tumor progression by activating the PI3K-Akt signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	LETM2 could activate the downstream PI3K-Akt pathway to participate in PDAC development
	LETM2 may activate the downstream PI3K-Akt signaling pathway through enhancing the level of PI3K phosphorylation as well as Akt phosphorylation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in squamous lung carcinomas tumoral     --over   was correlated with poor outcomes of pancreatic ductal adenocarcinoma (PDAC)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS