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FLASH GENE
Symbol LDLRAD3 contributors: mct - updated : 17-04-2023
HGNC name low density lipoprotein receptor class A domain containing 3
HGNC id 27046
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ectodomain containing three LDLa repeats
  • a transmembrane domain, and a cytoplasmic domain containing a conserved dileucine internalization motif and two polyproline motifs
    • conjugated LipoP
    HOMOLOGY
    Homologene
    FAMILY
  • LDLR family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane receptor
    basic FUNCTION
  • its expression significantly decreases the cellular half-life of mature APP
  • is a receptor for Venezuelan equine encephalitis virus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • influences APP processing, raising the possibility that LRAD3 alters APP function in neurons, including its downstream signaling
  • DPP4, AGTR2, SLC4A1, KREMEN1, ASGR1, ANP, TMEM30A, CLEC4G, and LDLRAD3, along with ACE2 facilitate SARS-CoV-2. virus entry and transmission
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • pathogenesis of VEEV infection is abrogated in mice with deletions in Ldlrad3