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FLASH GENE
Symbol LDLRAD2 contributors: mct - updated : 17-04-2023
HGNC name low density lipoprotein receptor class A domain containing 2
HGNC id 32071
Location 1p36.12      Physical location : 22.138.757 - 22.151.714
Synonym name low density lipoprotein receptor A domain containing 2
DNA
TYPE functioning gene
STRUCTURE 12.96 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4012 - 272 - 2021 33392788
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LDL receptor class A domain
  • conjugated LipoP
    HOMOLOGY
    Homologene
    FAMILY
  • LDLR family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • promoted epithelial-mesenchymal transition, migration and invasion, and metastasis of gastric cancer cells
  • LDLRAD2 may be an oncogene in pancreatic cancer via modulating Akt/mTOR signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in gastric cancer (GC), and closely correlated with poor prognosis
    tumoral     --over  
    in pancreatic cancer tissues and cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    LDLRAD2/ Wnt/β-catenin axis may be a potential therapeutic target for GC treatment
    ANIMAL & CELL MODELS