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FLASH GENE

Symbol

LCE3C

contributors: mct/npt - updated : 17-03-2022

HGNC name	late cornified envelope 3C
HGNC id	16612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility (De Cid 2009) constitutional   deletion     deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with psoriasis and psoriatic arthritis

Susceptibility

to psoriasis (see PSORS4)

Variant & Polymorphism insertion/deletion	deleted in a significant fraction of individuals of European ancestry with psoriasis (De Cid 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS