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FLASH GENE

Symbol

LCE3C

contributors: mct/npt - updated : 17-03-2022

HGNC name	late cornified envelope 3C
HGNC id	16612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21.3      Physical location : 152.573.137 - 152.573.562
Synonym name	small proline rich-like (epidermal differentiation complex) 3A
	late envelope protein 15
Synonym symbol(s)	LEP15, SPRL3A

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	member of the late cornified envelope (LCE) gene cluster
STRUCTURE	0.85 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178434 2 - 431 NP_848521 9.6 94 - 2016 27048876

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin       specific

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

LCE family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION
text	expressed at an early time point during epidermal differentiation in the suprabasal layers

basic FUNCTION	encoding stratum-corneum protein (Jackson 2005)
	LCE2C, LCE3C have distinct functions in epidermal biology
	potential role in epidermal host defense for LCE3 proteins and LCE3B/C-del-mediated psoriasis risk

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

in normal epidermis by skin barrier disruption (de Cid 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility (De Cid 2009) constitutional   deletion     deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with psoriasis and psoriatic arthritis

Susceptibility

to psoriasis (see PSORS4)

Variant & Polymorphism insertion/deletion	deleted in a significant fraction of individuals of European ancestry with psoriasis (De Cid 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS