Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LCE3B contributors: npt/mct - updated : 17-03-2022
HGNC name late cornified envelope 3B
HGNC id 29462
Location 1q21.3      Physical location : 152.586.286 - 152.586.573
Synonym name late envelope protein 14
Synonym symbol(s) LEP14
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text members of the late cornified envelope (LCE) gene cluster
STRUCTURE 0.28 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 288 - 95 - 2017 28634035
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin   specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Sprrl1 (79.8pc)
Homologene
FAMILY
  • LCE family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • encoding stratum-corneum protein (Jackson 2005)
  • potential role in epidermal host defense for LCE3 proteins and LCE3B/C-del-mediated psoriasis risk
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by in normal epidermis by skin barrier disruption (de Cid 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility (De Cid 2009
    constitutional   deletion    
    deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with psoriasis and psoriatic arthritis
    Susceptibility ton psoriasis (see PSORS4)
    Variant & Polymorphism insertion/deletion deleted in a significant fraction of individuals of European ancestry with psoriasis (De Cid 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS