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FLASH GENE
Symbol LCE3A contributors: mct - updated : 17-03-2022
HGNC name late cornified envelope 3A
HGNC id 29461
Location 1q21.3      Physical location : 152.595.310 - 152.595.579
Synonym name late envelope protein 13
Synonym symbol(s) LEP13, MGC184217
DNA
TYPE functioning gene
STRUCTURE 0.27 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 270 - 89 - 2016 27048876
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • LCE family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • LCE3A, have defensin-like antimicrobial activity against a variety of bacterial taxa at low micromolar concentrations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis
    Variant & Polymorphism SNP
  • a regulatory SNP at the putative enhancer of the LCE3A gene within the epidermal differentiation complex that showed epistatic interaction with HLA-Cw6 in psoriasis
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS