Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol L3MBTL3 contributors: mct - updated : 02-05-2018
HGNC name l(3)mbt-like 3 (Drosophila)
HGNC id 23035
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three MBT repeats
  • one SAM (sterile alpha motif) domain
    • HOMOLOGY
    interspecies homolog to murine L3mbtl3 (88.0pc)
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • Polycomb group protein specifically regulating the maturational advancement of myeloid progenitor cells during transitions between two developmental stages
  • may be influencing myelopoiesis by transiently enhancing p57(KIP2) expression levels
  • recognizes mono- and dimethylated lysine residues on histone tails
  • L3MBTL3 engages likely methylated histone tails as a dimer while carrying out its normal function, providing an explanation for the presence of repeated MBT domains within L3MBTL3
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the absence of NOTCH intracellular domain (NOTCH ICD), RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS