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FLASH GENE

Symbol

L3MBTL3

contributors: mct - updated : 02-05-2018

HGNC name	l(3)mbt-like 3 (Drosophila)
HGNC id	23035

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       intestine small intestine     highly Endocrine adrenal gland         Nervous nerve cranial nerve     highly Reproductive male system testis       Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three MBT repeats
	one SAM (sterile alpha motif) domain

HOMOLOGY

interspecies

homolog to murine L3mbtl3 (88.0pc)

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	Polycomb group protein specifically regulating the maturational advancement of myeloid progenitor cells during transitions between two developmental stages
	may be influencing myelopoiesis by transiently enhancing p57(KIP2) expression levels
	recognizes mono- and dimethylated lysine residues on histone tails
	L3MBTL3 engages likely methylated histone tails as a dimer while carrying out its normal function, providing an explanation for the presence of repeated MBT domains within L3MBTL3

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

in the absence of NOTCH intracellular domain (NOTCH ICD), RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS