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FLASH GENE
Symbol KLHL26 contributors: mct - updated : 11/06/2024
HGNC name kelch-like 26 (Drosophila)
HGNC id 25623
DNA
TYPE functioning gene
STRUCTURE 34.69 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4449 - 604 - 2020 31985165
3 - 4351 - 615 - 2020 31985165
3 - 3231 - 644 - 2020 31985165
4 - 1705 - 145 - 2020 31985165
3 - 519 - 102 - 2020 31985165
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 thymus    
Nervousbrain    
Reproductivefemale systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BACK (BTB/Kelch associated) domain
  • one BTB(POZ) domain
  • six Kelch repeats
    • HOMOLOGY
    interspecies homolog to murine Klhl26 (86.8pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may have likely an important role in ubiquitin-mediated protein degradation during cardiac development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLHL26 is a TP53 target gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in head and neck squamous cell or ovarian carcinomas
    Susceptibility to Ebstein's anomaly and left ventricular noncompaction
    Variant & Polymorphism
  • variant (p.R237C) associated with a familial case of Ebstein's anomaly and left ventricular noncompaction
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS