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FLASH GENE
Symbol KLHL24 contributors: mct - updated : 26-01-2017
HGNC name kelch-like 24 (Drosophila)
HGNC id 25947
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Skin/Tegumentskin     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificfibroblast Homo sapiens
Skin/Tegumentkeratinocyte Homo sapiens
Skin/Tegumentmelanocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • in the N terminus, BTB (bric a brac 1, tramtrack, and broad) domains facilitate dimerization and protein binding
    • HOMOLOGY
    interspecies homolog to murine Klhl24 (99.3pc)
    homolog to rattus Klhl24 (99.3pc)
    Homologene
    FAMILY
  • BTB/kelch family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in diverse cellular functions, including cytoskeleton interactions, nuclear transcription, and ubiquitination
  • can directly regulate native kainate receptors and involved in direct functional regulation of a glutamate receptor GRIK2
  • in addition to a previously demonstrated direct interaction with the GRIK2 C-terminal domain, regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect
  • role for KLHL24 in maintaining the balance between intermediate filament stability and degradation required for skin integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the GRIK2 C-terminal domain at a site distinct from the PDZ-binding motif
  • binds within a 58 amino acid segment of GRIK2 proximal to the plasma membrane
  • KRIP6 interacts with PICK1 in heterologous cells
  • interacts with PICK1 in heterologous cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EBSSH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS