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FLASH GENE
Symbol KLHL24 contributors: mct - updated : 26-01-2017
HGNC name kelch-like 24 (Drosophila)
HGNC id 25947
Corresponding disease
EBSSH epidermolysis bullosa simplex, generalized, with scarring and hair loss
Location 3q27.1      Physical location : 183.353.410 - 183.402.302
Synonym name
  • DRE1 protein
  • kainate receptor interacting protein for GluR6
  • kelch-like protein 24
  • Synonym symbol(s) DRE1, FLJ20059, KRIP6, FLJ25796
    DNA
    TYPE functioning gene
    STRUCTURE 48.89 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 7331 68.23 600 - 2008 18692513
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificfibroblast Homo sapiens
    Skin/Tegumentkeratinocyte Homo sapiens
    Skin/Tegumentmelanocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • in the N terminus, BTB (bric a brac 1, tramtrack, and broad) domains facilitate dimerization and protein binding
  • HOMOLOGY
    interspecies homolog to murine Klhl24 (99.3pc)
    homolog to rattus Klhl24 (99.3pc)
    Homologene
    FAMILY
  • BTB/kelch family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in diverse cellular functions, including cytoskeleton interactions, nuclear transcription, and ubiquitination
  • can directly regulate native kainate receptors and involved in direct functional regulation of a glutamate receptor GRIK2
  • in addition to a previously demonstrated direct interaction with the GRIK2 C-terminal domain, regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect
  • role for KLHL24 in maintaining the balance between intermediate filament stability and degradation required for skin integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the GRIK2 C-terminal domain at a site distinct from the PDZ-binding motif
  • binds within a 58 amino acid segment of GRIK2 proximal to the plasma membrane
  • KRIP6 interacts with PICK1 in heterologous cells
  • interacts with PICK1 in heterologous cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EBSSH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS