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FLASH GENE
Symbol EMX1 contributors: MCT/npt - updated : 16-01-2008
HGNC name empty spiracles homeobox 1
HGNC id 3340
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila empty spiracles (ems)1,Dres 93
    homolog to murine Emx1
    homolog to C.elegans k09f5.4
    Homologene
    FAMILY
  • EMX homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons
    basic FUNCTION
  • involved in brain development
  • functioning in combinations with OTX1/2 to specify cells fates in the developing central nervous system
  • suppress choroid plexus development and promote neuroepithelial cell fate
  • homeodomain transcription factor involved in the development of olfactory neurons
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text neural development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deletion of Lhx2 with Emx1-cre at embryonic day 10.5 (E10.5) altered the fates of progenitors, causing them to generate three-layer cortex, phenocopying olfactory cortex rather than lateral neocortex (Chou 2009)