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FLASH GENE
Symbol CILP2 contributors: mct - updated : 14-11-2012
HGNC name cartilage intermediate layer protein 2
HGNC id 24213
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TSP-1 domain suggesting that it may be able to anchor to other matrix constituents
    • HOMOLOGY
    intraspecies homolog to CILP
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
    text
  • localized in the deeper intermediate zone of the articular cartilage extracellular matrix at maturity
    • basic FUNCTION
  • CILP and CILP2 may be important in cartilage structure and disease
  • CILP and CILP2 can have additional roles in noncartilaginous tissue ECM structure and function
  • ECM protein that may be components of such permanent cartilages, rather than the transient growth plate cartilage
  • may contribute to the structural organization and matrix architecture within these connective tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • may be part of collagen VI containing suprastructures in human articular cartilage
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be associated with collagen VI microfibrils and thus may mediate interactions between matrix components in the territorial and inter-territorial articular cartilage matrix
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker could be potential biomarkers of arthritis or of metalloprotease activity in articular cartilage
    Therapy target
    ANIMAL & CELL MODELS
  • Cilp2 gene expression is dysregulated during cartilage degeneration in a mouse model of osteoarthritis reduced severalfold compared with sham operated joints