Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CASZ1

contributors: SGE/shn - updated : 21-03-2012

HGNC name	castor zinc finger 1
HGNC id	26002

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

eight C2H2-type zinc fingers

HOMOLOGY

interspecies	ortholog to CASZ1, Pan troglodytes
	homolog to Drosophila castor
	ortholog to casz1, Danio rerio
	ortholog to Casz1, Mus musculus

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	in the perinuclear region

basic FUNCTION	a zinc-finger transcription factor in a region implicated in neuroblastoma tumorigenesis
	controls apoptosis and tumor formation (
	regulates the expression of genes involved in regulation of cell growth and developmental processes (
	a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human neuroblastoma (
	is required to directly regulate an EGFL7/RhoA-mediated pathway to promote vertebrate vascular development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+ binding

protein

transcriptional pathway involving activation of EGFL7 gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in many human cancer cell lines, localizing to a chromosomal region frequently lost in tumors of neuroectodermal origin (Liu 2006)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS