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FLASH GENE

Symbol

CASZ1

contributors: SGE/shn - updated : 21-03-2012

HGNC name	castor zinc finger 1
HGNC id	26002

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	149.44 kb     21 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D1S244 - D1S2736 - CASZ1 - D1S1635 - D1S2740 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001079843 21 splicing 7938 NP_001073312 - 1759 - Liu (2006), Yuan 2005 also called CASZ11, or variant 1/isoform a localize predominantly in the nucleus, consistent with its role as Zn-finger containing transcription factor 11 zinc fingers NM_017766 16 splicing 4421 NP_060236 - 1166 - Liu (2006), Yuan (2005) also called CASZ5, or variant 2/isoform b localize predominantly in the nucleus, consistent with its role as Zn-finger containing transcription factor 5 zinc fingers

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular         moderately Homo sapiens Digestive intestine large intestine colon   moderately Homo sapiens   intestine       moderately Homo sapiens   liver       highly Homo sapiens   stomach       moderately Homo sapiens Lymphoid/Immune spleen       moderately Homo sapiens Nervous brain       moderately Homo sapiens Reproductive female system placenta     highly Homo sapiens   male system testis       Homo sapiens Respiratory lung       highly Homo sapiens Urinary kidney       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately Homo sapiens

cell lineage
cell lines	HL60, Jurket, ECV, Hey, Ln Cap, MDMAMB468, SK-N-SH, SKOV3, MCK 11.5, Sup T13, DU145, Hela, HUH7, PT67, T47DT1, U4A, MCF-7, SK-N-MC (
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

eight C2H2-type zinc fingers

HOMOLOGY

interspecies	ortholog to CASZ1, Pan troglodytes
	homolog to Drosophila castor
	ortholog to casz1, Danio rerio
	ortholog to Casz1, Mus musculus

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	in the perinuclear region

basic FUNCTION	a zinc-finger transcription factor in a region implicated in neuroblastoma tumorigenesis
	controls apoptosis and tumor formation (
	regulates the expression of genes involved in regulation of cell growth and developmental processes (
	a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human neuroblastoma (
	is required to directly regulate an EGFL7/RhoA-mediated pathway to promote vertebrate vascular development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+ binding

protein

transcriptional pathway involving activation of EGFL7 gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in many human cancer cell lines, localizing to a chromosomal region frequently lost in tumors of neuroectodermal origin (Liu 2006)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS