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FLASH GENE
Symbol KATNAL2 contributors: mct - updated : 10-12-2019
HGNC name katanin p60 subunit A-like 2
HGNC id 25387
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Katnal2 (86.5pc)
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus
text
  • is localized to basal bodies, ciliary axonemes, centrioles, and mitotic spindles
    • basic FUNCTION
  • multitasking enzyme involved in the same cell type in critically important processes affecting cytokinesis, Microtubule dynamics, and ciliogenesis and also implicated in cell cycle progression 2)
  • critical roles for KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth from the basal body, sperm head shaping via the manchette, acrosome attachment, and ultimately sperm release
  • functions likely in multiple aspects of haploid male germ cell development
  • is similarly required for cytokinesis, cell cycle progression, and ciliogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS