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FLASH GENE
Symbol KATNAL2 contributors: mct - updated : 10-12-2019
HGNC name katanin p60 subunit A-like 2
HGNC id 25387
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3443 - 564 - 2016 26929214
14 - 3334
18 - 3440 - 563 - 2016 26929214
15 - 3162 - 427 - 2016 26929214
16 - 2830 - 485 - 2016 26929214
14 - 2634 - 351 - 2016 26929214
13 - 2561 - 280 - 2016 26929214
16 - 1705 - 374 - 2016 26929214
15 - 2460 - 478 - 2016 26929214
13 - 2278 - 374 - 2016 26929214
12 - 2179 - 341 - 2016 26929214
16 - 2893 - 538 - 2016 26929214
15 - 2877 - 466 - 2016 26929214
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Katnal2 (86.5pc)
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus
text
  • is localized to basal bodies, ciliary axonemes, centrioles, and mitotic spindles
  • basic FUNCTION
  • multitasking enzyme involved in the same cell type in critically important processes affecting cytokinesis, Microtubule dynamics, and ciliogenesis and also implicated in cell cycle progression 2)
  • critical roles for KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth from the basal body, sperm head shaping via the manchette, acrosome attachment, and ultimately sperm release
  • functions likely in multiple aspects of haploid male germ cell development
  • is similarly required for cytokinesis, cell cycle progression, and ciliogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS