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FLASH GENE

Symbol

KATNAL2

contributors: mct - updated : 10-12-2019

HGNC name	katanin p60 subunit A-like 2
HGNC id	25387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.1      Physical location : 44.526.786 - 44.628.613
Synonym name	p60 katanin-like 2
Synonym symbol(s)	MGC33211, DKFZP667C165
EC.number	5.6.1.1

DNA

TYPE	functioning gene
STRUCTURE	187.25 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001353899 18 - 3443 NP_001340828 - 564 - 2016 26929214 NM_001353904 14 - 3334 NM_001353900 18 - 3440 NP_001340829 - 563 - 2016 26929214 NM_001353903 15 - 3162 NP_001340832 - 427 - 2016 26929214 NM_001353901 16 - 2830 NP_001340830 - 485 - 2016 26929214 NM_001353907 14 - 2634 NP_001340836 - 351 - 2016 26929214 NM_001353909 13 - 2561 NP_001340838 - 280 - 2016 26929214 NM_001353905 16 - 1705 NP_001340834 - 374 - 2016 26929214 NM_001353902 15 - 2460 NP_001340831 - 478 - 2016 26929214 NM_001353906 13 - 2278 NP_001340835 - 374 - 2016 26929214 NM_001353908 12 - 2179 NP_001340837 - 341 - 2016 26929214 NM_001367621 16 - 2893 NP_001354550 - 538 - 2016 26929214 NM_031303 15 - 2877 NP_112593 - 466 - 2016 26929214

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Katnal2 (86.5pc)

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus
text	is localized to basal bodies, ciliary axonemes, centrioles, and mitotic spindles

basic FUNCTION	multitasking enzyme involved in the same cell type in critically important processes affecting cytokinesis, Microtubule dynamics, and ciliogenesis and also implicated in cell cycle progression 2)
	critical roles for KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth from the basal body, sperm head shaping via the manchette, acrosome attachment, and ultimately sperm release
	functions likely in multiple aspects of haploid male germ cell development
	is similarly required for cytokinesis, cell cycle progression, and ciliogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS