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FLASH GENE

Symbol

ZNF628

contributors: npt - updated : 29-01-2010

HGNC name	zinc finger protein 628
HGNC id	28054

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.16 kb     3 Exon(s)

regulatory sequence	Binding site
text structure	ZEC binding DNA sequence,
	C/GA/TA/TGGTTGGTTGC, the GT box not containing binding sites for other previously characterized transcription factors and thus represented a potentially novel DNA target sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033113 3 - 3867 NP_149104 - 1055 - Chen (2004)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Respiratory lung         Skin/Tegument skin         Urinary bladder         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

18 C2H2 zinc fingers which were organized in two clusters

HOMOLOGY

Homologene

FAMILY

zinc fingers protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	could activate a reporter luciferase gene driven by this DNA sequence
	zinc finger protein having a novel binding specificity and transcription regulatory activity

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS