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FLASH GENE
Symbol IMP4 contributors: - updated : 07-09-2006
HGNC name IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id 30856
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Lymphoid/Immunelymph node    
 spleen    
 tonsils    
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one Brix domain
  • conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Imp4 (97.3pc)
    homolog to rattus Imp4 (97.9pc)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the early cleavages during pre-18S ribosomal RNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
  • component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein interacting with KIF20B
    cell & other
    REGULATION
    Other the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS