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FLASH GENE

Symbol

IMP4

contributors: - updated : 07-09-2006

HGNC name	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id	30856

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Lymphoid/Immune lymph node           spleen           tonsils         Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one Brix domain

conjugated

RiboP

HOMOLOGY

interspecies	homolog to murine Imp4 (97.3pc)
	homolog to rattus Imp4 (97.9pc)

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION

required for the early cleavages during pre-18S ribosomal RNA processing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
	component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B

INTERACTION

DNA

RNA

binding

small molecule

protein

interacting with KIF20B

cell & other

REGULATION

Other

the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS